Transient hyperglycemia at admission and acute ischemic stroke severity and short-term outcome

K. Tziomalos, P. Dimitriou, S. D. Bouziana, M. Spanou, S. Kostaki, S. Angelopoulou, M. Papadopoulou, V. Giampatzis, C. Savopoulos, A. I. Hatzitolios



Stress hyperglycemia is frequent during acute ischemic stroke. However, it is unclear whether it only reflects stroke severity or if it directly contributes to adverse outcome. To address this question, we prospectively studied 790 consecutive patients with acute ischemic stroke. Stress hyperglycemia was defined as fasting serum glucose levels at the second day after admission ≥126 mg/dl in non-diabetic patients. Patients with stress hyperglycemia had more severe stroke. However, stress hyperglycemia did not predict adverse outcome at discharge or in-hospital mortality in multivariate analyses adjusting for stroke severity. In conclusion, stress hyperglycemia does not appear to directly affect the outcome of acute ischemic stroke.

Keywords: ischemic stroke, outcome, stress hyperglycemia, type 2 diabetes mellitus