Pathophysiological mechanisms of dyslipidemia in patients with nephrotic syndrome: A fresh look

M.S. Elisaf, S. Filippas-Ntekouan



Qualitative and quantitative lipoprotein abnormalities are commonly found in patients with nephrotic syndrome irrespective of the underlying renal disease, including elevated triglycerides, LDL cholesterol, and Lp(a) levels, increased postprandial lipemia, as well as increased concentrations of TRG-rich lipoproteins containing ApoB, while various disturbances of the metabolism of HDL particles are also noticed. These lipid derangements play a prominent role in the pathogenesis of the cardiovascular disease as well as in the evolution of the underlying renal disease. In this review a detailed analysis of the pathogenetic mechanisms of dyslipidemia in this population is attempted.

Keywords: nephrotic syndrome, dyslipidemia, PCSK9, increased LDL CHOL levels