Low-density lipoprotein cholesterol targets: lowest is best

Maria Papagianni, Achilleas Papagiannis, Konstantinos Tziomalos



Data from both observational studies and from large randomized controlled trials (RCT) with statins, as well as emerging data from RCTs with other lipid-lowering agents, show that achieving low-density lipoprotein cholesterol (LDL-C) levels considerably lower than the currently recommended is both safe and also results in further reductions in cardiovascular events. In fact, until now, a threshold of LDL-C levels where safety concerns arise and cardiovascular risk reduction disappears has not been identified. Therefore, current LDL-C targets might have to be further reduced, particularly in very high risk patients.

Keywords: low-density lipoprotein cholesterol, targets, statins