Maria Papagianni, Achilleas Papagiannis, Konstantinos Tziomalos
Data from both observational studies and from large randomized controlled trials (RCT) with statins, as well as emerging data from RCTs with other lipid-lowering agents, show that achieving low-density lipoprotein cholesterol (LDL-C) levels considerably lower than the currently recommended is both safe and also results in further reductions in cardiovascular events. In fact, until now, a threshold of LDL-C levels where safety concerns arise and cardiovascular risk reduction disappears has not been identified. Therefore, current LDL-C targets might have to be further reduced, particularly in very high risk patients.
Keywords: low-density lipoprotein cholesterol, targets, statins