A case of uncommon cause of hypercholesterolemia

Sempastian Filippas-Ntekouan, Maria Kosmidou, Constantinos Tellis, Alexandros D Tselepis, Haralampos Milionis



Cholestasis is a rare cause of secondary hypercholesterolemia which may be attributed to increased production of an abnormal lipoprotein (apo), known as Lp-X. We present the case of a patient admitted due to cholestatic jaundice and pruritus and showed excess hypercholesterolemia due to increased production of Lp-X. The patient was diagnosed with an adenocarcinoma of the pancreas. Surgical restoration of the bile flow resulted in normalization of lipids.

Keywords: Secondary hypercholesterolemia, lipoprotein X, cholestasis, jaundice